School of Biomedical Sciences

  1. Background
  2. Contact
  3. Publications

Webba da Silva, Mateus Dr

Reader in Pharmaceutical Chemistry

Academic and Professional Qualifications
- 1996: PhD in Chemistry, University of Exeter

Career History
- 2011 - Present: Reader in Pharmaceutical Chemistry, University of Ulster, Coleraine.
- 2005 - 2011: Lecturer in Pharmaceutical Chemistry, University of Ulster, Coleraine.
- 2001- 2005: Senior Research Associate; Duke University, Durham (NC), USA.
- 1999 - 2001: Research Associate, Memorial Sloan-Kettering Cancer Center, New York (NY), USA.
- 1997 - 1999: Postdoctoral Associate, University of California, Davis (CA), USA.
- 1996 - 1997: Postdoctoral Fellow, Royal Institute of Technology (KTH), Stockholm, Sweden.

Teaching & Learning Activities
- Organic & Medicinal Chemistry, Spectroscopy, Drug Discovery & Development, Research Methodologies.

Research Interests

Research in our laboratory involves nucleic acids structural studies with themes encompassing dimensions from the atomic to the nanosize scale. Current efforts focus on developing understanding, and making use, of their programmable self-assembly. Applications include unravelling mechanistic aspects of self-assembly of four-stranded DNA regions contributing to regulation of gene expression, and the development of entities with electronic, catalytic, medicinal, or simply structural properties.

Webba da Silva, Mateus Dr - Contact details

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Dr Mateus Webba da Silva
Reader
 Biomedical Sciences Research Institute

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Room Y027
School of Biomedical Sciences
University of Ulster
Coleraine campus
Cromore Road
Coleraine
Co. Londonderry
BT52 1SA
phone: +44 28 70124009
Email: mm.webba-da-silva@ulster.ac.uk

Webba da Silva, Mateus Dr - Publications

Number of items: 24.

Trajkovski, Marko, Webba da Silva, Mateus and Plavec, Janez (2012) Unique structural features of interconverting monomeric and dimeric G-quadruplexes adopted by a sequence from intron of N-myc gene. Journal of the American Chemical Society, 134.

Karsisiotis, Ioannis, Ma’ani Hessari, N, Novellino, E, Spada, GP, Randazzo, A and Webba da Silva, Mateus (2011) Topological Characterization of G-Quadruplexes by UV Absorption and Circular Dichroism. Angewandte Chemie International Edition, 50. pp. 10645-10648.

Eritja, R, Mergny, J.L., Montesarchio, D, Spindler, L and Webba da Silva, Mateus (2010) G-Quadruplex Nucleic Acids. Journal of Nucleic Acids, 2010 (Article ID 147650).

Groves, P and Webba da Silva, Mateus (2010) Rapid Stoichiometric Analysis of G-Quadruplexes in Solution. Chem. Eur. J., 16. pp. 6451-6453.

Spindler, L, Rigler, R, Drevenˇsek-Olenik, I, Ma’ani Hessari, N and Webba da Silva, Mateus (2010) Effect of Base Sequence on G-Wire Formation in Solution. Journal of Nucleic Acids, 2010 (Article ID 431651,).

Webba da Silva, Mateus, Trajkovski, Marko, Sannohe, Yuta, Hessari, Nason, Sugiyama, Hiroshi and Plavec, Janez (2009) Design of a G-Quadruplex Topology through Glycosidic Bond Angles. Angewandte Chemie International Edition, 48.

Webba da Silva, Mateus (2007) Geometric Formalism for DNA Quadruplex F olding. Chem. Eur. J., 13.

Webba da Silva, Mateus (2007) NMR methods for studying quadruplex nucleic acids. Methods, 43.

Mergny, J.L., De Cian, A, Amrane, S and Webba da Silva, Mateus (2006) Kinetics of double-chain reversals bridgingcontiguous quartets in tetramolecular quadruplexes. Nucleic Acids Research, 34.

Adams, DJ, Webba da Silva, Mateus, Kohlhagen, G, Pommier, Y, Colvin, OM, Manikumar, G and Wani, MC (2005) Camptothecin analogs with enhanced activity against human breastcancer cells. I. Correlation of potency with lipophilicity and persistence inthe cleavage complex. Cancer Chemother Pharmacol, 57.

Webba da Silva, Mateus, Bierbryer, RG, Wilds, CJ, Noronha, AM, Miller, PS and Gamcsik, MP (2005) Intrastrand base-stacking buttresses widening of major groovein interstrand cross-linked B-DNA. Bioorganic & Medicinal Chemistry, 13.

Noll, DM, Webba da Silva, Mateus, Noronha, AM, Wilds, CJ, Colvin, OM, Gamcsik, MP and Miller, PS (2005) Structure, Flexibility, and Repair of Two Different Orientations of the Same AlkylInterstrand DNA Cross-Link†. Biochemistry, 44.

Webba da Silva, Mateus (2005) Experimental Demonstration of T:(G:G:G:G):T Hexad and T:A:A:T TetradAlignments within a DNA Quadruplex Stem. Biochemistry, 44.

Webba da Silva, Mateus, Wilds, CJ, Noronha, AM, Colvin, OM, Miller, PS and Gamcsik, MP (2004) Accommodation of Mispair Aligned N3T-Ethyl-N3T DNA Interstrand Cross Link. Biochemistry, 43.

Webba da Silva, Mateus (2003) Association of DNA Quadruplexes through G:C:G:C Tetrads. Solution Structure ofd(GCGGTGGAT). Biochemistry, 42.

Webba da Silva, Mateus, Noronha, AM, Noll, DM, Miller, PS, Colvin, OM and Gamcsik, MP (2002) Solution Structure of a DNA Duplex Containing Mispair-AlignedN4C-Ethyl-N4C Interstrand Cross-Linked Cytosines†. Biochemistry, 41.

Webba da Silva, Mateus, Sham, S, Gorst, CM, Calzolai, L, Brereton, PS, Adams, MWW and La Mar, GN (2001) Solution NMR Characterization of the Thermodynamics of the Disulfide BondOrientational Isomerism and Its Effect of Cluster Electronic Properties for theHyperthermostable Three-Iron Cluster Ferredoxin from the Archaeon Pyrococcusfuriosus. Biochemistry, 40.

Orrell, KG, Osborne, AG, Sik, V, Webba da Silva, Mateus, Hursthouse, MB, Hibbs, DE, Abdul Malik, KM and Vassilev, NG (1998) Stereochemically non-rigid transition metal complexes of2,6-bis[1-(phenylimino)ethyl]pyridine (BIP). Part 3. Dynamic NMRstudies of fac-[PtXMe3(BIP)] (X C1, Br, or I). Crystal structure offac-[PtIMe3(BIP)]. Journal of Organometallic Chemistry, 555. pp. 35-47.

Maliarik, M, Glaser, J, Toth, Imre, Webba da Silva, Mateus and Zekany, L (1998) A New Class of Oligonuclear Platinum-Thallium Compounds with a DirectMetal2Metal Bond3. Unusual Equilibria in Aqueous Solution. Eur. J. Inorg. Chem., 1998. pp. 565-570.

Orrell, KG, Osborne, AG, Webba da Silva, Mateus, Hursthouseb, MB and Coles, SJ (1997) Preparation and characterisation of rhenium(I)and platinum(IV) complexes of 2,6-bis(pyrazol-lylmethyl)pyridine and 2,6=bis(3,5-dimethylpyrazol-1-ylmethyl)pyridine. Crystalstructure of fac-[ReI(CO),(BMPz)]. Polyhedron, 16. pp. 3003-3017.

Orrell, KG, Osborne, AG, Sik, V and Webba da Silva, Mateus (1997) Stereochemically non-rigid transition metal complexes of2,6-bis[(1-phenylimino) ethyl]pyridine (BIP)Part 1. Dynamic NMR studies of[M( C6F 5) 2(BIP)] (M = Pd II or Pt II). Journal of Organometallic Chemistry, 530. pp. 235-246.

Orrell, KG, Osborne, AG, Sik, V, Webba da Silva, Mateus, Hursthouse, MB, Hibbs, DE, Abdul Malik, KM and Vassilev, NG (1997) Stereochemically non-rigid transition metal complexes of2,6-bis[(1-phenylimino)ethyl]pyridine (BIP)Part 2. Dynamic NMR studies of fac-[ReX(CO)3(BIP)](X = C1, Br, or I).Crystal structure of fac-[ReBr(CO)3(BIP)]. Journal of Organometallic Chemistry, 538. pp. 171-183.

Osborne, AG, Webba da Silva, Mateus, Hursthouse, MB, Malik, KMA, Opromolla, G and Zanello, P (1996) Synthetic, structural and electrochemical studieson some ferrocenylazines: crystal structuresof [4]( 1)( 1,4-dimethyl-2,3-diazabuta- 1,3-dien) ferrocenophaneand [42 ](1,1') bis( 1,4-dimethyl-2,3-diazabuta- 1,3-dien) ferrocenophane. Journal of Organometallic Chemistry, 516. pp. 167-176.

Orrell, KG, Osborne, AG, Sik, V and Webba da Silva, Mateus (1995) NMR STUDIES OF FLUXIONAL RHENIUM CARBONYLCOMPLEXES OF 2,6-DIACETYLPYRIDINE (DAP),fac-[ReX ( CO )a(D AP)] . Polyhedron, 14. pp. 2797-2802,.

This list was generated on Thu May 17 03:33:19 2012 BST.