School of Biomedical Sciences

Background
Contact
Publications

McKelvey-Martin, Valerie Professor

Head of Engagement and Professor of Molecular Biosciences

Academic and Professional Qualifications

1983: SRN BSc, Nursing Studies (First Class Honours), University of Ulster., Coleraine
1986: PhD, Genetics, University of Ulster, Coleraine
1991: MI Biol, C.Biol, Institute of Biology, 2009, Fellow of Society of Biology (FSB)
1992: Postgraduate Certificate in Teaching (with commendation) University of Ulster, Jordanstown
2010: Postgraduate Certificate in Social Research Skills (with distinction) University of Ulster, Magee.

Career History
2010-present: Head of Engagement, Dept Pharmacy & Pharmaceutical Sciences
2008-2010: Deputy Head of Dept, Pharmacy & Pharmaceutical Sciences
2006-2008: Subject Head for Pharmacy and Pharmacology
2005-present: Science in Society director
2003-2007: Head of School of Biomedical Sciences
2003-present: Professor in Molecular Biosciences University of Ulster, Coleraine
1999-2003: Reader in Molecular Biology, Biomedical Sciences, University of Ulster, Coleraine
1995-1999: Senior Lecturer in Molecular Biology, University of Ulster, Coleraine
1989-1995: Lecturer in Molecular Biology, University of Ulster, Coleraine
1987-1989: Research Officer in Molecular Biology, NI Centre for Genetic Engineering, The Queen’s University of Belfast.
1986-1987:Research Officer in Molecular Biology, Biomedical Sciences Research Centre, University of Ulster, Coleraine

Teaching and Learning Activities

Molecular Biology, Medical Cell Biology

Research Interests DNA damage and repair, carcinogenesis, Neurofibromatosis1, Community of Scientific Enquiry and Public Engagement in Science.

Recent Publications

Watson, JA, McKenna, DJ, Maxwell, P, Diamond, J, Arthur, K, McKelvey-Martin, VJ and Hamilton, PW. (2010) Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganisation and altered gene expression profiles. Journal of Cellular and Molecular Medicine (IF 6.8) Jun;14 (6B):1668-82. E pub ahead of print July 6th 2009).

McKelvey-Martin, VJ and McKenna, DJ, Developments and Applications of the Comet –FISH assay for the study of DNA damage and repair, in The Comet Assay in Toxicology (Eds: Dr Alok Dhawan & Professor Diana Anderson) The Royal Society of Chemistry, London 2009. Ch 9:129-150.

McKenna, DJ, McKeown, SR, and McKelvey-Martin, VJ, (2008) Potential use of the comet assay in the clinical management of cancer. Mutagenesis;( doi: 10.1093/mutage/gem 054) Mutagenesis 23:3 183-190

Dunlop,L, Humes,G, Clarke,L and McKelvey-Martin,V. ( 2011) Developing communities of enquiry: dealing with social and ethical issues in science at key stage 3. School Science Review. (in press).

McKelvey-Martin, Valerie Professor - Contact details

Professor Valerie McKelvey-Martin
Professor of Molecular Biosciences
Biomedical Sciences Research Institute

Room Y139
School of Biomedical Sciences
University of Ulster
Coleraine campus
Cromore Road
Coleraine
Co. Londonderry
BT52 1SA

phone: +44 28 70124771
Email: v.mckelvey@ulster.ac.uk

McKelvey-Martin, Valerie Professor - Publications

Number of items: 25.
Watson, Jenny A, McKenna, Declan J, Maxwell, Perry, Diamond, James, Arthur, Ken, McKelvey-Martin, Valerie J and Hamilton, Peter W (2010) Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles. Journal of Cellular and Molecular Medicine, 14 (6b). pp. 1668-1682 .
McKelvey-Martin, Valerie J and McKenna, Declan J (2009) Chapter 6. Development and Applications of the Comet -FISH Assay for the Study of Damage and Repair. In: The Comet Assay in Toxicology. The Royal Society of Chemistry, pp. 129-150. ISBN 978-0-85404-199-2
Wasson, Gillian R, McKelvey-Martin, Valerie and Downes, Stephen (2008) The use of the comet assay in the study of human nutrition and cancer. MUTAGENESIS, 23 (3). pp. 153-162.
McKenna, Declan J, McKeown, Stephanie and McKelvey-Martin, Valerie (2008) Potential use of the comet assay in the clinical management of cancer. MUTAGENESIS, 23 (3). pp. 183-190.
McKelvey-Martin, Valerie, ed. (2008) Mutagenesis Special Issue : The Comet assay. 97 pp. Oxford University Press. ISBN 1464-3804
Wasson, Gillian R, McGlynn, Angela P, McNulty, Helene, O'Reilly, Sharleen L, McKelvey-Martin, Valerie, McKerr, George, Strain, JJ, Scott, John and Downes, Stephen (2006) Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation. JOURNAL OF NUTRITION, 136 (11). pp. 2748-2753.
Rajab, Nor F, McKenna, Declan J, Diamond, Jim, Williamson, Kate, Hamilton, Peter W and McKelvey-Martin, Valerie (2006) Prediction of radiosensitivity in human bladder cell lines using nuclear chromatin phenotype. CYTOMETRY PART A, 69A (10). pp. 1077-1085.
Doherty, Sharon C, McKeown, Stephanie R, Lopez, Jesus A, Walsh, Ian K and McKelvey-Martin, Valerie (2006) Gene expression in normal Urothelium depends on location within the bladder: A possible link to bladder carcinogenesis. EUROPEAN UROLOGY, 50 (2). pp. 290-301.
Doherty, Sharon C, McKeown, SR, Lopez, Jesus A, Walsh, Ian K and McKelvey-Martin, Valerie J (2006) Gene expression in normal Urothelium depends on location within the bladder: A possible link to bladder carcinogenesis. European Urology, 50 (2). pp. 290-301.
Doherty, SC, McKeown, Stephanie, McKelvey-Martin, Valerie, Downes, Stephen, Atala, A, Yoo, JJ, Simpson, DA and Kaufmann, WK (2003) Cell cycle checkpoint function in bladder cancer. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 95 (24). pp. 1859-1868.
McKeown, Stephanie, Robson, T, Price, ME, Ho, ETS, Hirst, DG and McKelvey-Martin, Valerie (2003) Potential use of the alkaline comet assay as a predictor of bladder tumour response to radiation. BRITISH JOURNAL OF CANCER, 89 (12). pp. 2264-2270.
O'Connor, JM, Bonham, MP, Turley, E, McKeown, A, McKelvey-Martin, VJ, Gilmore, WS and Strain, JJ (2003) Copper supplementation has no effect on markers of DNA damage and liver function in healthy adults (FOODCUE project). ANNALS OF NUTRITION AND METABOLISM, 47 (5). pp. 201-206.
McKenna, DJ, Gallus, M, McKeown, Stephanie, Downes, Stephen and McKelvey-Martin, Valerie (2003) Modification of the alkaline Comet assay to allow simultaneous evaluation of mitomycin C-induced DNA cross-link damage and repair of specific DNA sequences in RT4 cells. DNA REPAIR, 2 (8). pp. 879-890.
McGlynn, AP, Wasson, GR, O'Reilly, S, McKelvey-Martin, Valerie, McNulty, Helene, Strain, Sean, McKerr, George, Mullan, F, Mahmud, N, Scott, J, Weir, DG and Downes, Stephen (2003) Detection of replicative integrity in small colonic biopsies using the BrdUrd comet assay. BRITISH JOURNAL OF CANCER, 88 (6). pp. 895-901.
McKenna, Declan J, Rajah, NF, McKeown, Stephanie, McKerr, George and McKelvey-Martin, Valerie (2003) Use of the comet-FISH assay to demonstrate repair of the TP53 gene region in two human bladder carcinoma cell lines. RADIATION RESEARCH, 159 (1). pp. 49-56.
Price, ME, McKelvey-Martin, Valerie, Robson, T, Hirst, DG and McKeown, Stephanie (2000) Induction and rejoining of DNA double-strand breaks in bladder tumor cells. RADIATION RESEARCH, 153 (6). pp. 788-794.
Robson, T, Price, ME, Moore, ML, Joiner, MC, McKelvey-Martin, Valerie, McKeown, Stephanie and Hirst, DG (2000) Increased repair and cell survival in cells treated with DIR1 antisense oligonucleotides: implications for induced radioresistance. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 76 (5). pp. 617-623.
McGlynn, AP, Wasson, G, O'Connor, Jacqueline, McKerr, George, McKelvey-Martin, Valerie and Downes, Stephen (1999) The bromodeoxyuridine comet assay: Detection of maturation of recently replicated DNA in individual cells. CANCER RESEARCH, 59 (23). pp. 5912-5916.
Hughes, CM, McKelvey-Martin, Valerie and Lewis, SEM (1999) Human sperm DNA integrity assessed by the Comet and ELISA assays. MUTAGENESIS, 14 (1). pp. 71-75.
Welch, Rob, Turley, E, Sweetman, SF, Kennedy, G, Collins, AR, Dunne, A, Livingstone, Barbara, McKenna, PG, McKelvey-Martin, VJ and Strain, Sean (1999) Dietary antioxidant supplementation and DNA damage in smokers and nonsmokers. Nutrition and Cancer-an International Journal, 34 (2). pp. 167-172.
Hughes, Ciara, Lewis, SEM, McKelvey-Martin, Valerie and Thompson, W (1998) The effects of antioxidant supplementation during Percoll preparation on human sperm DNA integrity. HUMAN REPRODUCTION, 13 (5). pp. 1240-1247.
McKelvey-Martin, Valerie, Ho, ETS, McKeown, Stephanie, Johnston, SR, McCarthy, PJ, Rajab, NF and Downes, Stephen (1998) Emerging applications of the single cell gel electrophoresis (Comet) assay. I. Management of invasive transitional cell human bladder carcinoma. II. Fluorescent in situ hybridization Comets for the identification of damaged and repaired DNA sequences in individual cells. MUTAGENESIS, 13 (1). pp. 1-8.
Best, CJ, McKenna, PG and McKelvey-Martin, Valerie (1997) Mutagen sensitivity in thymidine kinase- and methyltransferase-deficient human lymphoblastoid cells. BRITISH JOURNAL OF BIOMEDICAL SCIENCE, 54 (4). pp. 267-272.
Sweetman, SF, Strain, JJ and McKelvey-Martin, VJ (1997) Effect of antioxidant vitamin supplementation on DNA damage and repair in human lymphoblastoid cells. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 27 (2). pp. 122-130.
Gilmore, WS, McKelvey-Martin, VJ, Rutherford, S, Strain, JJ, Loane, P, Kell, M and Millar, S (1994) HUMAN MILK CONTAINS GRANULOCYTE COLONY STIMULATING FACTOR. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 48 (3). pp. 222-224.
This list was generated on Thu May 17 03:07:17 2012 BST.