School of Biomedical Sciences

Background
Contact
Publications

McCarron, Paul Professor

Head of Department of Pharmacy

Academic and Professional Qualifications
1988: BSc Hons Pharmacy, Queen’s University of Belfast.
1990: Member Pharmaceutical Society of Northern Ireland.
1993: PhD Drug Delivery, Queen’s University of Belfast.
1994: Postgraduate Certificate in Management Practice, University of Ulster.
1998: Postgraduate Certificate in Higher Education and Teaching, Queen’s University of Belfast.
2000: Radiation Protection Supervisor, National Radiological Protection Board, Chilton

Career History
2008 - present: Professor of Pharmaceutics, University of Ulster, Coleraine.
2006 - 2008: Senior Lecturer in Pharmaceutical Chemistry, School of Pharmacy, Queen’s University of Belfast.
1997 - 2006: Lecturer in Pharmaceutical Chemistry, School of Pharmacy, Queen’s University of Belfast.
1995 - 1996: Postdoctoral Research Fellow, School of Pharmacy, Queen’s University of Belfast.
1993 - 1995: Formulation Pharmacist, Galen Pharmaceuticals Ltd., Portadown.
1990 - 1993: Research Assistant, School of Pharmacy, Queen’s University of Belfast.
1989 - 1990: Formulation Pharmacist, Norbrook Laboratories, Newry.

Teaching & Learning Activities
Pharmaceutical methods of analysis; drug delivery technologies; bioadhesive systems; particulate drug delivery systems.

Research Interests
Nanoparticles and nanomedicines; photodynamic therapy; topical hydrogel drug delivery systems for wound management; patent technologies for transdermal drug delivery.

Three Recent Publications
Scott CJ, Marouf WM, Quinn DJ, Buick RJ, Orr SJ, Donnelly RF, McCarron PA. Immunocolloidal targeting of the endocytotic siglec-7 receptor using peripheral attachment of siglec-7 antibodies to poly(lactide-co-glycolide) nanoparticles. Pharmaceutical Research. 25: 135-146, 2008.

McCarron PA and Hall M. Incorporation of novel 1-alkylcarbonyl-oxymethyl prodrugs of 5-fluorouracil into poly(lactide-co-glycolide) nanoparticles. International Journal of Pharmaceutics. 348: 115-124, 2008.

McCarron PA, Donnelly RF, Woolfson AD. Autoradiographic and scintillation analysis of 5-aminolevulinic acid permeation through epithelialised tissue: implications for topical photodynamic therapy of superficial gynaecological neoplasias. Pharmaceutical Research. 25: 812-826, 2008.

McCarron, Paul Professor - Contact details

Professor Paul McCarron
Professor of Pharmaceutics
Biomedical Sciences Research Institute

Room Y146
School of Biomedical Sciences
University of Ulster
Coleraine campus
Cromore Road
Coleraine
Co. Londonderry
BT52 1SA

phone: +44 28 70123285
Email: p.mccarron@ulster.ac.uk

McCarron, Paul Professor - Publications

Number of items: 37.

Fay, Francois, Scott, Christopher J. and McCarron, P. A. (2010) Recent Innovations in Antibody-Mediated, Targeted Particulate Nanotechnology and Implications for Advanced Visualisation and Drug Delivery. CURRENT NANOSCIENCE, 6 (6). pp. 560-570.

Morrow, Desmond I. J., McCarron, P. A., Woolfson, A. David, Juzenas, Petras, Juzeniene, Asta, Iani, Vladimir, Moan, Johan and Donnelly, Ryan F. (2010) Novel patch-based systems for the localised delivery of ALA-esters. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 101 (1). pp. 59-69.

Morrow, Desmond I. J., McCarron, P. A., Woolfson, A. David, Juzenas, Petras, Juzeniene, Asia, Iani, Vladimir, Moan, Johan and Donnelly, Ryan F. (2010) Hexyl Aminolaevulinate Is a More Effective Topical Photosensitiser Precursor than Methyl Aminolaevulinate and 5-Aminolaevulinic Acids When Applied in Equimolar Doses. JOURNAL OF PHARMACEUTICAL SCIENCES, 99 (8). pp. 3486-3498.

Morrow, Desmond I. J., McCarron, P. A., Woolfson, A. David, Juzenas, Petras, Juzeniene, Asta, Iani, Vladimir, Moan, Johan and Donnelly, Ryan F. (2010) Influence of penetration enhancers on topical delivery of 5-aminolevulinic acid from bioadhesive patches. JOURNAL OF PHARMACY AND PHARMACOLOGY, 62 (6, Sp. Iss. SI). pp. 685-695.

Fay, Francois, Quinn, Derek J., Gilmore, Brendan F., McCarron, P. A. and Scott, Christopher J. (2010) Gene delivery using dimethyldidodecylammonium bromide-coated PLGA nanoparticles. BIOMATERIALS, 31 (14). pp. 4214-4222.

McCarron, P. A. and Faheem, A. M. (2010) Nanomedicine-based cancer targeting: a new weapon in an old war. NANOMEDICINE, 5 (1). pp. 3-5.

Magee, Justin, Winder, J. R., McClelland, Brian and McCarron, Paul (2009) Skin Marker.University of Ulster (2009) Skin Marker.

Singh, T. R. R., McCarron, Paul, Woolfson, A. D. and Donnelly, R. F. (2009) Physicochemical Characterization of Poly(ethylene glycol) Plasticized Poly(methyl vinyl ether-co-maleic acid) Films. Journal of Applied Polymer Science, 112 (5). pp. 2792-2799.

Singh, T. R. R., McCarron, Paul, Woolfson, A. D. and Donnelly, R. F. (2009) Investigation of swelling and network parameters of poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-co-maleic acid) hydrogels. European Polymer Journal, 45 (4). pp. 1239-1249.

Donnelly, R. F., Singh, T. R. R., Tunney, M. M., Morrow, D. I. J., McCarron, Paul, O'Mahony, C. and Woolfson, A. D. (2009) Microneedle Arrays Allow Lower Microbial Penetration Than Hypodermic Needles In Vitro. Pharmaceutical research, 26 (11). pp. 2513-2522.

Donnelly, R. F., Morrow, D. I. J., Singh, T. R. R., Migalska, K., McCarron, Paul, O'Mahony, C. and Woolfson, A. D. (2009) Processing difficulties and instability of carbohydrate microneedle arrays. Drug development and industrial pharmacy, 35 (10). pp. 1242-1254.

Donnelly, R. F., Morrow, D. I. J., McCarron, Paul, Woolfson, A. David, Morrissey, A., Juzenas, P., Juzeniene, A., Iani, V., McCarthy, H. O. and Moan, J. (2009) Microneedle Arrays Permit Enhanced Intradermal Delivery of a Preformed Photosensitizer. Photochemistry and photobiology, 85 (1). pp. 195-204.

Donnelly, R. F., McCarron, Paul, Al-Kassas, R., Juzeniene, A., Juzenas, P., Iani, V., Woolfson, A. D. and Moan, J. (2009) Influence of Formulation Factors on PpIX Production and Photodynamic Action of Novel ALA-loaded Microparticles. Biopharmaceutics & drug disposition, 30 (2). pp. 55-70.

Donnelly, R. F., Cassidy, C. M., Loughlin, R. G., Brown, A., Tunney, M. M., Jenkins, M. G. and McCarron, Paul (2009) Delivery of Methylene Blue and meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate from cross-linked poly(vinyl alcohol) hydrogels: A potential means of photodynamic therapy of infected wounds. Journal of Photochemistry and Photobiology B-Biology, 96 (3). pp. 223-231.

Cassidy, C. M., Tunney, M. M., McCarron, Paul and Donnelly, R. F. (2009) Drug delivery strategies for photodynamic antimicrobial chemotherapy: From benchtop to clinical practice. Journal of Photochemistry and Photobiology B-Biology, 95 (2). pp. 71-80.

Al-Kassas, R., Donnelly, R. F. and McCarron, Paul (2009) Aminolevulinic acid-loaded Witepsol microparticles manufactured using a spray congealing procedure: implications for topical photodynamic therapy. Journal of Pharmacy and Pharmacology, 61 (9). pp. 1125-1135.

Zawislak, A., Donnelly, R. F., McCluggage, W. G., Price, J. H., McClelland, H. R., Woolfson, A. D., Dobbs, S., Maxwell, P. and McCarron, P. A. (2009) Clinical and immunohistochemical assessment of vulval intraepithelial neoplasia following photodynamic therapy using a novel bioadhesive patch-type system loaded with 5-aminolevulinic acid. Photodiagnosis and Photodynamic Therapy, 6 (1). pp. 28-40.

Zawislak, A. A., McCluggage, W. G., Donnelly, R. F., Maxwell, P., Price, J. H., Dobbs, S. P., McClelland, H. R., Woolfson, A. D. and McCarron, P. A. (2009) Response of vulval lichen sclerosus and squamous hyperplasia to photodynamic treatment using sustained topical delivery of aminolevulinic acid from a novel bioadhesive patch system. Photodermatology Photoimmunology & Photomedicine, 25 (2). pp. 111-113.

Scott, C. J., Marouf, W. M., Quinn, D. J., Buick, R. J., Orr, S. J., Donnelly, R. F. and McCarron, Paul (2008) Immunocolloidal targeting of the endocytotic siglec-7 receptor using peripheral attachment of siglec-7 antibodies to poly(lactide-co-glycolide) nanoparticles. Pharmaceutical research, 25 (1). pp. 135-146.

Sibani, S. A., McCarron, Paul, Woolfson, A. D. and Donnelly, R. F. (2008) Photosensitiser delivery for photodynamic therapy. Part 2: systemic carrier platforms. Expert Opinion on Drug Delivery, 5 (11). pp. 1241-1254.

Singh, T. R. R., Donnelly, R. F., McCarron, Paul, Woolfson, D. A. and Morrow, D. I. J. (2008) Investigation of swelling and network parameters of poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-co-maleic anhydride) hydrogels. Journal of Pharmacy and Pharmacology, 60. pp. 32.

Morrow, D. I. J., McCarron, Paul, Juzenas, P., Iani, V., Moan, J. and Donnelly, R. F. (2008) Influence of chemical permeation enhancers on topical delivery of aminolevulinic acid from a novel bioadhesive patch. Journal of Pharmacy and Pharmacology, 60. pp. 54.

Morrow, D. I. J., McCarron, Paul, Gallagher, M., Migalska, K., Thakur, R., Morrissey, A., Woolfson, A. D. and Donnelly, R. F. (2008) Assessment of galactose microneedles for enhanced transdermal drug delivery. Journal of Pharmacy and Pharmacology, 60. pp. 96.

Singh, T. R. R., Quinn, G., Donnelly, R. F., McCarron, P. A. and Woolfson, A. D. (2008) In vitro investigation of silicon microneedle-mediated microbial penetration across a model membrane. Journal of Pharmacy and Pharmacology, 60. pp. 111.

Loughlin, R. G., Tunney, M. M., Donnelly, R. F., Murphy, D. F., Jenkins, M. and McCarron, Paul (2008) Modulation of gel formation and drug-release characteristics of lidocaine-loaded poly(vinyl alcohol)-tetraborate hydrogel systems using scavenger polyol sugars. European Journal of Pharmaceutics and Biopharmaceutics, 69 (3). pp. 1135-1146.

McCarron, Paul, Marouf, W. M., Quinn, D. J., Fay, F., Burden, R. E., Olwill, S. A. and Scott, C. J. (2008) Antibody targeting of camptothecin-loaded PLGA nanoparticles to tumor cells. Bioconjugate chemistry, 19 (8). pp. 1561-1569.

McCarron, Paul, Marouf, W. M., Donnelly, R. F. and Scott, C. (2008) Enhanced surface attachment of protein-type targeting ligands to poly(lactide-co-glycolide) nanoparticles using variable expression of polymeric acid functionality. Journal of Biomedical Materials Research Part a, 87A (4). pp. 873-884.

Migalska, K. E., Woolfson, A. D., McCarron, Paul, Morrow, D., Thakur, R. and Donnelly, R. F. (2008) Development of a model membrane representing skin with different water contents for investigation of drug release from polymeric microneedles. Journal of Pharmacy and Pharmacology, 60. pp. 135.

Singh, T. R. R., Donnelly, R. F. and McCarron, Paul (2007) Characterisation of poly(ethylene glycol) plasticized poly(methyl vinyl ether-co-maleic anhydride) films. Journal of Pharmacy and Pharmacology, 59. pp. 143.

Zawislak, A. A., McCarron, P. A., McCluggage, W. G., Donnelly, R. F., Price, J. H., McClelland, H. R. and Woolfson, A. D. (2007) Novel bioadhesive patch-type system for photodynamic vulvodynia therapy after delivery of 5-aminolevulinic acid - Preliminary evaluation. Journal of Reproductive Medicine, 52 (7). pp. 645-653.

Ahmadi, S., McCarron, P. A., Donnelly, R. F., Woolfson, A. D. and McKenna, K. (2004) Evaluation of the penetration of 5-aminolevulinic acid through basal cell carcinoma: a pilot study. Experimental dermatology, 13 (7). pp. 445-451.

Zawislak, A. A., McCarron, P. A., McCluggage, W. G., Price, J. H., Donnelly, R. F., McClelland, H. R., Dobbs, S. P. and Woolfson, A. D. (2004) Successful photodynamic therapy of vulval Paget's disease using a novel patch-based delivery system containing 5-aminolevulinic acid. Bjog-an International Journal of Obstetrics and Gynaecology, 111 (10). pp. 1143-1145.

Sidhu, H. K., Price, J. H., McCarron, Paul, McCafferty, D. F., Woolfson, A. D., Biggart, D. and Thompson, W. (1997) A randomised controlled trial evaluating a novel cytotoxic drug delivery system for the treatment of cervical intraepithelial neoplasia. British journal of obstetrics and gynaecology, 104 (2). pp. 145-149.

Woolfson, A. D., McCafferty, D. F., McCarron, P. A. and Price, J. H. (1995) Autoradiographic Imaging of the Distribution of 5-Fluorouracil through Cervical Tissue Following In-Vitro Surface Application of a Bioadhesive Cervical Patch. Pharmaceutical research, 12 (5). pp. 676-681.

Woolfson, A. D., McCafferty, D. F., McCarron, P. A. and Price, J. H. (1995) A Bioadhesive Patch Cervical Drug-Delivery System for the Administration of 5-Fluorouracil to Cervical Tissue. Journal of Controlled Release, 35 (1). pp. 49-58.

Woolfson, A. D., McCafferty, D. F., McCarron, P. A. and Price, J. H. (1994) Liquid Scintillation Spectrometry of 5-Fluorouracil in Cervical Tissue Following In-Vitro Surface Application of a Bioadhesive Cervical Patch. Pharmaceutical research, 11 (9). pp. 1315-1319.

Woolfson, A. D., McCafferty, D. F., Gorman, S. P., McCarron, P. A. and Price, J. H. (1992) Design of an Apparatus Incorporating a Linear Variable Differential Transformer for the Measurement of Type-Iii Bioadhesion to Cervical Tissue. International journal of pharmaceutics, 84 (1). pp. 69-76.

This list was generated on Thu May 17 03:01:19 2012 BST.